Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of recombinant human matriptase 2 using Boc-Gln-Ala-Arg-AMC as substrate at 3.85 to 385 nM preincubated for 30 mins followed by substrate addition and measured for 40 mins by microplate reader method
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
TMPRSS2 pericellular activity screening assay from Article 10.1038/s41586-022-04661-w: "A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic."
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Matriptase Inhibition from US Patent US10988505: "Matriptase inhibitors and uses thereof"
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Reversible inhibition of recombinant human C-terminal V5-His-tagged matriptase-2 expressed in Drosophila S2 cells assessed as dissociation half time using Boc-Gln-Ala-ArgAMC as substrate measured for 1200 mins by fluorescence assay
Assay data:3 Tested
Inhibition of recombinant human C-terminal V5-His-tagged matriptase-2 expressed in Drosophila S2 cells using Boc-Gln-Ala-ArgAMC as substrate measured for 1200 mins by fluorescence assay
Assay data:29 Active, 1 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Human transmembrane serine protease 6 (S1: Chymotrypsin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human matriptase-2 transfected in HEK cells assessed as residual activity at 5 uM using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
Assay data:1 Tested
Inhibition of human matriptase-2 transfected in HEK cells assessed as residual activity at 40 uM using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
Assay data:27 Tested
Inhibition of matriptase (unknown origin) using Ac-RQFRpNA substrate by spectrophotometry method
Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis
Assay data:15 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of matriptase-2 (unknown origin) expressed in HEK293 cells using ln-Ala-Arg-a-Arg-para-nitroanilide as substrate by UV-vis spectrophotometry
Assay data:32 Active, 13 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrophotometry
Assay data:2 Active, 73 Tested
Tight binding inhibition of human matriptase2 expressed in Drosophila melanogaster S2 cells using Boc-QAR-AMC as substrate incubated for 15 mins prior to substrate addition measured for 30 mins by fluorimetric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of matriptase 2
Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 mins
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 mins
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on