Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Measurement of Binding Affinity for Human ABHD6 from US Patent US11981682: "Substituted cyclopenta[c]pyrroles as ABHD6 antagonists"
Assay data:20 Active, 4 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Evaluation of ABHD6 Enzyme Inhibitory Activity from US Patent US11981682: "Substituted cyclopenta[c]pyrroles as ABHD6 antagonists"
Assay data:20 Active, 14 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Biological Assay from US Patent US11974987: "Monoacylglycerol lipase modulators for use in autism spectrum disorders"
Assay data:121 Active, 18 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 121 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Data from US Patent US11891387: "Monoacylglycerol lipase modulators"
Assay data:105 Active, 1 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 108 Tested
hABHD6 Endocannabinoid related and lipase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
hFAAH Endocannabinoid related and lipase panel
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
[3H] 2-OG cleavage activity assay (rat brain)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
[3H] 2-OG cleavage activity assay (mouse brain)
[3H] 2-OG cleavage activity assay (PBMC)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
[3H] 2-OG cleavage activity assay (HeLa)
Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as substrate incubated for 1 hr
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse brain FAAH
Inhibition of ABHD6 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human ABHD6 expressed in HEK293T cells assessed as inhibition constant using 2-AG as substrate incubated for 30 mins by fluorescence plate reader assay
Inhibition of human ABHD6 expressed in HEK293 cells using TAMRA-FP as substrate by SDS-PAGE gel based competitive ABPP assay
Inhibition of ABHD6 in mouse brain membrane using HT-01 probe as substrate incubated for 30 mins by gel based competitive ABPP assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of ABHD6 in mouse brain membrane using TAMRA-FP as substrate at 10 uM pre-incubated for 30 mins followed by substrate addition and measured after 20 mins by coomassie staining based gel competitive ABPP assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant ABHD6
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using 1-AG as substrate incubated for 90 mins by sensitive fluorescence glycerol assay
Inhibition of ABHD6 in mouse brain membrane using FP-biotin as substrate incubated for 1 hr by LC-MS based ABPP-MudPIT analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on