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Biochemical Potency on JAK1, JAK2, JAK3 and Tyk2 from US Patent US20240209001: "HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from US Patent US12018014: "Pyrrole-substituted indolone derivative or pharmaceutically acceptable salts thereof, and preparation method therefor and application thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition Tests on JAK-1, JAK-2 and JAK-3 Kinases from US Patent US11993603: "Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof"
Assay data:28 Active, 11 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
In Vitro JAK Kinase Assay from US Patent US11992490: "Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
Biochemical Potency JAK1 Assay from US Patent US20240166651: "HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS"
Assay data:10 Active, 8 Activity ≤ 1 µM, 10 Tested
JAK2 Activity Inhibitory Assay from US Patent US20240150367: "NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF"
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
JAK3 Activity Inhibitory Assay from US Patent US20240150367: "NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF"
Assay data:67 Active, 66 Activity ≤ 1 µM, 67 Tested
In Vitro JAK Kinase Assay from US Patent US11957661: "JAK1 pathway inhibitors for the treatment of vitiligo"
JAK2 Binding Assay from US Patent US20240116892: "HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS"
Assay data:263 Active, 254 Activity ≤ 1 µM, 264 Tested
Radiometric Assay from US Patent US20240140952: "INHIBITORS AND DEGRADERS OF JANUS KINASE 2"
Assay data:15 Active, 9 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Biochemical Kinase Assay Protocol (JAK) from US Patent US20240132525: "BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF"
Assay data:90 Active, 39 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
ADP-Glo Kinase Assay from US Patent US20240109890: "BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
JAK2 Z-Lyte Biochemical Assay from US Patent US20240101559: "TRICYCLIC KINASE INHIBITORS AND USES THEREOF"
Assay data:9 Active, 1 Activity ≤ 1 µM, 11 Tested
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:14 Active, 1 Activity ≤ 1 µM, 34 Tested
Assay data:34 Active, 22 Activity ≤ 1 µM, 34 Tested
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
In Vitro JAK Kinase Assay from US Patent US11918581: "Combination therapy comprising JAK pathway inhibitor and rock inhibitor"
TBD from US Patent US20240059694: "COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF"
Assay data:28 Active, 30 Activity ≤ 1 µM, 30 Tested
In Vitro JAK Kinase Assay from US Patent US20240058343: "TREATMENT OF URTICARIA USING JAK INHIBITORS"
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