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Competitive displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM after 2 mins by FACScan flow cytometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Ratio of inhibition of BODIPY-GDP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) to BODIPY-GTP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Allosteric inhibition of BODIPY-GDP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as nucleotide release at 10 uM preincubated for 2.5 hrs with BODIPY-GDP followed by compound addition by FACScan flow cytometry
Allosteric inhibition of BODIPY-GTP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as nucleotide release at 10 uM preincubated for 2.5 hrs with BODIPY-GTP followed by compound addition by FACScan flow cytometry
Competitive inhibition of BODIPY-GDP binding to nucleotide binding site of GST-tagged Rab7 GTPase T22N mutant (unknown origin) expressed in Escherichia coli BL21(DE3) 100 nM after 2.5 hrs by FACScan flow cytometry
Competitive inhibition of BODIPY-GTP binding to nucleotide binding site of GST-tagged Rab7 GTPase Q67L mutant (unknown origin) expressed in Escherichia coli BL21(DE3) 100 nM after 2.5 hrs by FACScan flow cytometry
Competitive inhibition of BODIPY-GDP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) 200 nM using varying BODIPY-GDP levels after 2.5 hrs by FACScan flow cytometry
Competitive inhibition of BODIPY-GTP binding to nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) 100 nM using varying BODIPY-GTP levels after 2.5 hrs by FACScan flow cytometry
Displacement of BODIPY-GDP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 1 to 10 uM after 2 hrs by flow cytometry
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 1 to 10 uM after 2 hrs by flow cytometry
Displacement of BODIPY-GDP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 2 hrs by flow cytometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 2 hrs by flow cytometry relative to untreated control
Assay data:2 Active, 3 Tested
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 2 hrs by flow cytometry
Assay data:4 Active, 4 Activity ≤ 1 µM, 7 Tested
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in Mg buffer assessed as residual activity after 2 hrs by flow cytometry
Assay data:21 Tested
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in Mg buffer after 2 hrs by flow cytometry
Assay data:20 Active, 20 Activity ≤ 1 µM, 22 Tested
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in EDTA buffer assessed as residual activity after 2 hrs by flow cytometry
Assay data:22 Tested
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in EDTA buffer after 2 hrs by flow cytometry
Assay data:22 Active, 19 Activity ≤ 1 µM, 22 Tested
Binding affinity to Rab7 GTPase N161T mutant (unknown origin) assessed as equilibrium dissociation constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of wild-type GFP-tagged Rab7 in human HeLa cell lysate assessed as reduction in EGF induced EGFR lysosomal degradation at 10 to 100 uM preincubated for 3 hrs followed by EGF addition measured after 15 to 120 mins by immunoblot analysis
Inhibition of Rab7 in human SCC-12F cells assessed as reduction in EGF induced EGFR lysosomal degradation preincubated for 30 mins followed by EGF addition measured after 15 to 180 mins by SDS-PAGE
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