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Inverse agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inverse agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to control
Assay data:21 Tested
Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
Assay data:16 Active, 14 Activity ≤ 1 µM, 22 Tested
Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to LysoPS(18:1)
Assay data:6 Tested
Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to LysoPS(18:1)
Assay data:16 Tested
Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 21 Tested
PRESTO-Tango GPCRome screening (GPR174)
SummaryRelated BioAssays by Target
Inverse agonist activity at GPR174 in anti-CD3/CD28-stimulated human PBMCs assessed as reduction in FoxP3-positive Helios-positive nTreg cells at 30 uM after 7 days by flow cytometric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inverse agonist activity at GPR174 in anti-CD3/CD28-stimulated human PBMCs assessed as reduction in FoxP3-positive Helios-positive nTreg cells after 7 days by flow cytometric analysis
Inverse agonist activity at GPR174 in anti-CD3/CD28-stimulated human PBMCs assessed as reduction in FoxP3-positive Helios-positive nTreg cells at 100 uM after 7 days by flow cytometric analysis
Inverse agonist activity at GPR174 in anti-CD3/CD28-stimulated human PBMCs assessed as increase in FoxP3-positive Helios-negative T cells at 100 uM after 3 days by flow cytometric analysis
Allosteric modulator activity at human GPR174 by CRA
Assay data:4 Active, 3 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonist activity at human GPR174 by CRA
Inverse agonist activity at human GPR174 assessed as fold decrease in Gs signalling activity by CRA
Assay data:51 Tested
Inverse agonist activity at human GPR174 by CRA
Assay data:6 Active, 8 Activity ≤ 1 µM, 51 Tested
Antagonist activity at human GPR174 assessed as decrease in Gs signalling in presence of LysoPS measured up to 30 mins by Glosensor assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonist activity at GPR174 (unknown origin) expressed in HEK293 cells assessed as inhibition of PS-induced GPR174 signaling incubated for 15 mins by GloSensor assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 7 Tested
Antagonist activity at GPR174 (unknown origin) expressed in HEK293 cells assessed as inhibition of PS-induced GPR174 signaling at 1 to 2 uM incubated for 15 mins by GloSensor assay
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