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Inhibition of KCC2 (unknown origin) transfected in HEK293 cells assessed a reduction in TI influx at 10 uM incubated for 1 hr by fluorescence based analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Human K-Cl cotransporter 2 (SLC12 family of cation-coupled chloride transporters)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ratio of IC50 for ML077 to compound IC50 for KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase at 2 uM after 8 mins by fluorescence analysis
Antagonist activity at KCC2 expressed in human HEK293 cells assessed as [86Rb] uptake after 30 mins by scintillation counting
Assay data:2 Active, 2 Tested
Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase after 8 mins by fluorescence analysis
Assay data:11 Active, 7 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase at 2 uM after 8 mins by fluorescence analysis
Assay data:10 Tested
Inhibition of rat KCC2 expressed in human Sk-Hep cells assessed as induction off Rb+ flux by atomic absorption spectroscopic analysis
Assay data:9 Active, 7 Activity ≤ 1 µM, 12 Tested
Antagonist activity of rat KCC2 transporter expressed in human SK-Hep cells assessed as inhibition of N-ethylmaleimide-mediated Rb+ influx after 10 mins by atomic absorption spectroscopy
Assay data:32 Active, 18 Activity ≤ 1 µM, 42 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Antagonist Probe Summary
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Dose-dependent Assay 3 with KCC2
Assay data:3 Active, 7 Activity ≤ 1 µM, 62 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2
Assay data:92 Active, 29 Activity ≤ 1 µM, 609 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux
Assay data:22 Active, 3 Activity ≤ 1 µM, 26 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Dose-Dependent Assay 2 with KCC2
Assay data:8 Active, 3 Activity ≤ 1 µM, 62 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 2 with KCC2 cells
Assay data:867 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 3 with KCC2 cells
Assay data:1815 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay with KCC2 cells
Assay data:546 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen
Assay data:4127 Active, 189275 Tested
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