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Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC4 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 4 Tested
Agonist activity at human TRPC4 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC5 stably expressed in HEK293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate reader assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked channel current measured at +80 mV by whole-cell voltage clamp assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of TRPC4 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intracellular Ca2+ level by Fluo-4 dye based FLIPR assay
Inhibition of TRPC5 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intracellular Ca2+ level by Fluo-4 dye based FLIPR assay
Assay data:17 Active, 14 Activity ≤ 1 µM, 34 Tested
Inhibition of human TRPC4 channel expressed in HEK293 cells assessed as inhibition of EA-evoked Calcium influx by measuring reduction in intracellular Ca2+ level and measured upto 360 sec by Fluo-4/AM dye based FLIPR assay
Assay data:1 Active, 2 Tested
Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked Calcium influx by measuring reduction in intracellular Ca2+ level and measured upto 360 sec by Fluo-4/AM dye based FLIPR assay
Assay data:22 Active, 6 Activity ≤ 1 µM, 36 Tested
Patch Clamp Assay from US Patent US9447114: "Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives"
Assay data:6 Active, 4 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
High Throughput Screening Assay from US Patent US9447114: "Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives"
Assay data:23 Active, 21 Activity ≤ 1 µM, 23 Tested
TRP selectivity screen (TRPC5)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human TRPC5 at <= 30 uM
Antagonist activity at human TRPC4 at <= 30 uM
Inhibition of human TRPC5 expressed in HEK293-T-REx cells assessed as decrease in riluzole-induced calcium response preincubated for 5 min followed by riluzole stimulation by Fluo-4 AM dye based FLIPR assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Potency index, ratio of test compound to englerin A for agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells
Assay data:3 Tested
Agonist activity at human TRPC5 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 10 nM measured at 5 secs interval for 300 secs by Fura-2AM dye based fluorescence assay
Assay data:2 Active, 5 Tested
Agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 1 uM measured at 5 secs interval for 300 secs in presence of TRPC4/5 antagonist Pico145 by Fura-2AM dye based fluorescence assay
Assay data:5 Tested
Agonist activity at human TRPC4/TRPC1 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 0.1 uM measured at 5 secs interval for 300 secs by Fura-2AM dye based fluorescence assay
Assay data:1 Active, 5 Tested
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