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PRESTO-Tango GPCRome screening (GPR77)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced TNFalpha release at 100 uM in presence of C5a1 antagonist PMX53 by ELISA
Assay data:2 Tested
Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced IL-6 release at 100 uM by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Agonist activity at C5a2 receptor in LPS-induced IHMDM assessed as effect on L10 release at 0.1 to 100 uM by ELISA
Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced TNFalpha release at 0.1 to 100 uM by ELISA
Agonist activity at C5a2 receptor in HMDM assessed as inhibition of LPS-induced IL-6 release at 10 to 100 uM by ELISA
Induction of C5a1-C5a2 heteromer formation (unknown origin) expressed in HEK293 cells at 100 uM by BRET assay
Partial agonist activity at human C5a2 receptor assessed as induction of beta-arrestin-2 recruitment by DiscoverX Path Hunter kit based assay
Assay data:2 Active, 2 Tested
Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay relative to C5a
Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay
Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay
Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes at 100 uM incubated for 1 hr by microbeta scintillation counting assay
Human C5a2 receptor (Complement peptide receptors)
Assay data:7 Active, 7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Mouse C5a2 receptor (Complement peptide receptors)
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