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Inhibition of recombinant full length C-Myc/DDK-tagged human SYNJ2 expressed in HEK293T cells using PI(3,4,5)P3 as substrate incubated for 8 mins assessed as hydrolysis of PI(3,4,5)P3 to PI(3,4)P2 by fluorescence polarization assay
Assay data:22 Active, 1 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of SYNJ2 in human MDA-MB-231 cells assessed as induction of EGFR localization within cells at 0.78 uM by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to C-Myc/DDK-tagged human recombinant SYNJ2 expressed in HEK293T cells by microscale thermophoresis assay
Inhibition of C-Myc/DDK-tagged human recombinant SYNJ2 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay
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