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Inhibition of Myc-tagged human Dusp1 expressed in TPA-stimulated human HeLa cells assessed as suppression of Dusp6-induced reduction in ERK phosphorylation at 0.5 to 2 uM by immunostaining based assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of His-tagged DUSP1 catalytic domain (152 to 323 residues) (unknown origin) using DiFMUP as substrate incubated for 30 mins by spectrofluorometric analysis
Assay data:6 Active, 22 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of His-tagged DUSP1 catalytic domain (152 to 323 residues) (unknown origin) using DiFMUP as substrate assessed as residual enzyme activity at 20 uM incubated for 30 mins by spectrofluorometric analysis relative to control
Assay data:24 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MKP2
Assay data:1 Active, 7 Tested
Inhibition of MKP1
Assay data:19 Tested
Inhibition of Myc-tagged human Dusp1 expressed in TPA-induced human HeLa cells assessed as decrease in dephosphorylation of pERK measured at 100 uM by immunostaining
Assay data:1 Tested
Inhibition of Myc-tagged human Dusp1 expressed in TPA-induced human HeLa cells assessed as decrease in dephosphorylation of pERK measured by immunostaining
Inhibition of recombinant MKP1
Assay data:5 Active, 4 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells
Assay data:4 Active, 1 Activity ≤ 1 µM, 15 Tested
Cdc25B Catalytic Domain Protein Tyrosine Phosphatase Probe Assessment: MKP-1 Dose Response Selectivity comparison.
Assay data:11 Active, 29 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
In vitro MKP-1 Phosphatase Dose Response SAR Support Assay
Assay data:5 Active, 47 Tested
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing
Assay data:41 Active, 58 Tested
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of Catalase
Assay data:33 Active, 58 Tested
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT
In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay
Assay data:49 Active, 118 Tested
In vitro MKP-1 Phosphatase Dose Response Confirmation and Secondary Selectivity/Specificity Assay
Assay data:6 Active, 6 Tested
In vitro Primary HTS Assay for MKP-1
Assay data:100 Active, 65239 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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