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Antagonist activity at Wnt3a-stimulaed human frizzled-5 expressed in human HEK293superTOP flash cells at 10 nM incubated for 24 hrs by luciferase reporter gene assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at Wnt3a-stimulaed frizzled-5 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
Agonist activity at frizzled-5 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assay
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation assessed as protein-compound complex formation at 5 to 50 uM by surface plasmon resonance assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of full length mouse Frizzled-8 transfected in Frizzled-1/2/7 knockout HEK293T cells using lentiviral expression system cotransfected with Renilla luciferase assessed as reduction in Wnt3a signaling by measuring luciferase activity at 64 uM measured after 24 hrs by Dual-Glo luciferase reporter assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length mouse Frizzled-8 transfected in Frizzled-1/2/7 knockout HEK293T cells using lentiviral expression system cotransfected with Renilla luciferase assessed as reduction in Wnt3a signaling by measuring luciferase activity at 8 to 64 uM measured after 24 hrs by Dual-Glo luciferase reporter assay
Assay data:1 Active, 1 Tested
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
Binding affinity to immobilized human Frizzled-5 CRD (P31 to Y150 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
Binding affinity to recombinant human Frizzled-8 (Ala25 to Pro172 residues)/human IgG1 chimeric protein expressed in CHO cells assessed as dissociation rate constant by SPR assay
Assay data:3 Tested
Binding affinity to recombinant human Frizzled-5 (Ala27 to Pro167 residues)/human IgG1 chimeric protein expressed in mouse NS0 cells by SPR assay
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