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Inhibition of SERCA1a in rabbit Sarcoplasmic reticulum assessed as inhibition constant in presence of [gamma-32P]ATP and calcium ionophore A23187 by by coupled enzyme assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enhancement of SERCA2a activity in STZ-induced diabetic rat model V-clamped myocytes assessed as effect on calcium transient amplitude at 1 uM by patch clamp method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Enhancement of SERCA2a activity in STZ-induced diabetic rat model V-clamped myocytes assessed as increased excitation release at 1 uM by patch clamp method
Enhancement of SERCA2a activity in STZ-induced diabetic rat model V-clamped myocytes assessed as acceleration of calcium transient decay at 1 uM by patch clamp method
Reversal of STZ-induced SERCA2a depression in STZ-induced diabetic rat model cardiac preparation assessed as increase in Vmax at 500 nM
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reversal of STZ-induced SERCA2a depression in STZ-induced diabetic rat model cardiac preparation assessed as increase in Vmax at 300 nM
Determination of Inhibitory Potencies by Coupled ATPase Activity Assay from Article 10.1016/j.bmc.2008.12.010: "Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation."
Assay data:2 Active, 19 Tested
Determination of Inhibitory Potencies by Coupled ATPase Activity Assay from Article 10.1016/j.bmc.2009.07.075: "Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase."
Assay data:8 Active, 2 Activity ≤ 1 µM, 12 Tested
Inhibition of rabbit skeletal muscle SERCA1 assessed as reduction in calcium uptake preincubated for 10 mins followed by ATP addition and measured after 4 mins by scintillation liquid method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of SERCA1 in rat INS-1E cells assessed as insulin release preincubated for 24 hrs followed by incubation in glucose-free buffer and measured after 30 mins by RIA
Assay data:7 Tested
Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring increase in late apoptotic cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry
Assay data:3 Active, 7 Tested
Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring increase in early apoptotic cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry
Assay data:6 Active, 7 Tested
Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring decrease in living cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry
Assay data:7 Active, 7 Tested
Inhibition of SERCA1 in glucose-stimulated rat INS-1E cells assessed as decline in insulin release preincubated for 24 hrs followed by glucose addition and measured after 30 mins by RIA
Binding affinity to transmembrane region of SERCA1A ATP binding site in NewZealand rabbit SR vesicles assessed as conformational changes by measuring intrinsic Trp fluorescence at IC50 incubated for 30 mins by spectrofluorometric analysis
Assay data:5 Active, 7 Tested
Binding affinity to cytosolic region of SERCA1 ATP binding site in NewZealand rabbit SR vesicles assessed as conformational changes by measuring decrease in fluorescence intensity at IC50 incubated for 1 hr by FITC probe labeling based analysis
Inhibition of SERCA1 in rat INS-1E cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay
Inhibition of SERCA1 in rabbit skeletal muscle microsomes assessed as decrease in NADH absorbance by NADH-coupled enzyme assay
Assay data:3 Tested
Inhibition of SERCA2 in C57BL/6 mouse primary neurons at 30 uM by UV-Vis spectrophotometric method relative to control
Assay data:1 Tested
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