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Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in PDPN O-GalNAc glycosylation by at 40 uM incubated for 48 hrs by jacalin lectin based immunoprecipitation analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ppGalNAcT2 in human RKO cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human SW480 cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human HCT116 cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human Jurkat cells assessed as reduction in O-GalNAc glycosylation by measuring VVA lectin expression at 40 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring PNA lectin expression at 20 to 60 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring VVA lectin expression at 20 to 60 uM incubated for 48 hrs by Western blot analysis
Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in O-GalNAc glycans by measuring PNA lectin signal on cell surface at 40 uM incubated for 48 hrs by DAPI staining based immunofluorescence method
Assay data:2 Active, 3 Tested
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 W282A mutant expressed in HEK293 cells using EA2 peptide as substrate by HPLC-based enzyme assay
Assay data:2 Active, 2 Tested
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc7 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc5AC peptide as substrate incubated for 30 mins by HPLC-based enzyme assay
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 using Muc2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay
Non-competitive inhibition of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells using UDP-GalNAc as substrate by HPLC-based enzyme assay
Competitive inhibition of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells using EA2 peptide as substrate by HPLC-based enzyme assay
Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation rate by SPR analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as association rate by SPR analysis
Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation constant by SPR analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293T cells and using 5-FAM labelled-EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 6 Tested
Inhibition of ppGalNAcT2 (unknown origin) in presence of OGT, EA2 and UDP-GlcNAc incubated for 25 mins at 37 degC
Assay data:2 Tested
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