Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
In Vitro Assay from US Patent US20240101531: "PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS"
Assay data:373 Active, 166 Activity ≤ 1 µM, 419 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potency index, ratio of retigabine EC50 to test compound EC50 for agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 0.1 uM by patch clamp method
Potency index, ratio of retigabine EC50 to test compound EC50 for anticonvulsant activity in Kv7.2/Kv7.3 (unknown origin) channel expressed in CHO cells
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control
Assay data:3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as leftward shift change in half activation potential at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based assay
Assay data:2 Active, 3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal at 10 uM by FluxOR fluorescent dye based assay
Assay data:29 Tested
Agonist activity at human KCNQ2/3 expressed in CHO cells assessed as increase in outward current at 10 uM by patch clamp electrophysiology method
Effect on human Kv7.3 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Inhibition of KCNQ2/3 (unknown origin) at a holding potential -40 mV at 30 uM by whole cell patch clamp electrophysiology relative to control
Assay data:2 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on