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Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation at 200 uM by UV-visible spectroscopic analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation at 25 uM by UV-visible spectroscopic analysis relative to control
Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation at 1 mM by UV-visible spectroscopic analysis relative to control
Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation at 10 uM by UV-visible spectroscopic analysis relative to control
Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by UV-visible spectroscopic analysis
Assay data:19 Active, 16 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by measuring inhibition constant by UV-visible spectroscopic analysis
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of IDO1 in MTAP knockout human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of IDO1 in human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrs
Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced Trp level at 5 uM pretreated with IFNgamma for 24 hrs followed by compound addition for 30 mins prior to Trp addition and measured after 30 mins by HPLC-MS/MS analysis
Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced Trp level at 1 mM pretreated with IFNgamma for 24 hrs followed by compound addition for 30 mins prior to Trp addition and measured after 30 mins by HPLC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced Trp level at 5 mM pretreated with IFNgamma for 24 hrs followed by compound addition for 30 mins prior to Trp addition and measured after 30 mins by HPLC-MS/MS analysis
Inhibition of IDO1 in human HeLa cells assessed as reduction in IFNgamma induced IDO1 protein expression level incubated for 24 hrs by immunoblotting analysis
Inhibition of IDO1 in human HeLa cells assessed as reduction in IFNgamma induced IDO1 mRNA expression level incubated for 24 hrs by qPCR analysis
Inhibition of IDO1 in HEK293T cells assessed as reduction in kynurenine level incubated for 24 hrs
Inhibition of IDO1 in HEK293T cells assessed as reduction in IFNgamma induced IDO1 protein expression incubated for 48 hrs
Inhibition of IDO1 in human HeLa cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs
Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21(DE3) preincubated for 40 mins followed by Trp addition and measured after 60 mins by LC-MS analysis
Assay data:2 Tested
Inhibition of IDO1 in human BXPC-3 cells assessed as increase in Trp level at 10 uM incubated for 48 hrs in presence of IFNgamma by LC-MS analysis
Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level at 10 uM incubated for 48 hrs by LC-MS analysis
Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysis
Assay data:15 Active, 8 Activity ≤ 1 µM, 24 Tested
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