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In Vitro FRET Assay from US Patent US11945784: "IRE1 small molecule inhibitors"
Assay data:65 Active, 56 Activity ≤ 1 nM, 65 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Kinase Activity Assay from US Patent US11840523: "IRE1α inhibitors and uses thereof"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of RNase Activity of IRE1alpha from US Patent US20230331719: "Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Kinase Activity of IRE1alpha from US Patent US20230331719: "Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Biochemical Assay from US Patent US11649237: "Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition"
Assay data:224 Active, 10 Activity ≤ 1 nM, 214 Activity ≤ 1 µM, 228 Tested
Inhibition of ERN1 (unknown origin) at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
ERN1 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
IRE1(h) Kinase panel
Inhibition of ERN1 (unknown origin) at 1 uM
Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysis
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ERN1 (unknown origin) at 10 uM incubated for 1 hr by qPCR analysis
Assay data:1 Active, 1 Tested
FRET-suppression assay from US Patent US10323013: "Inhibitors of the IRE-1/XBP-1 pathway and methods of using thereof"
Assay data:12 Active, 7 Activity ≤ 1 µM, 21 Tested
Inhibition Assay from US Patent US9493435: "IRE-1α inhibitors"
Assay data:112 Active, 174 Activity ≤ 1 µM, 174 Tested
Cell-Based Assay from US Patent US9241942: "IRE-1α inhibitors"
Assay data:10 Active, 1 Activity ≤ 1 µM, 183 Tested
In Vitro Enzyme Assay from US Patent US9241942: "IRE-1α inhibitors"
Assay data:250 Active, 176 Activity ≤ 1 µM, 278 Tested
In vitro RNase Assay from Article 10.1021/acschembio.5b00940: "Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands."
Assay data:25 Active, 15 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from Article 10.1021/acschembio.5b00940: "Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands."
Assay data:38 Active, 25 Activity ≤ 1 µM, 47 Tested
Inhibition Assay from US Patent US9040714: "IRE-1α inhibitors"
Assay data:132 Active, 129 Activity ≤ 1 µM, 137 Tested
In Vitro Enzyme Assays from US Patent US8614253: "IRE-1α inhibitors"
Assay data:245 Active, 171 Activity ≤ 1 µM, 272 Tested
In Vitro Assay from US Patent US9981901: "IRE-1α inhibitors"
Assay data:72 Active, 35 Activity ≤ 1 µM, 73 Tested
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