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Substrate uptake by the Organic Cation/Carnitine Transporter 1 (OCTN1, SLC22A4) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC22A4 (PubChem AID: 1794816)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Membrane potential based assay for SLC22A4 using HEK-293 SLC22A4 OE cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Drug transport assessed as OCTN2 transporter mediated cell permeability in human Caco2 cells across apical to basolateral side at 25 uM after 15 to 120 mins by UPLC-MS/MS method relative to gemcitabine
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug transport assessed as OCTN2 transporter mediated cell permeability in human Caco2 cells across apical to basolateral side at 25 uM after 15 to 120 mins by UPLC-MS/MS method
Drug transport assessed as Vmax for OCTN2 transporter mediated drug uptake in human Caco2 cells after 10 mins by Eadie-Hofstee plot method
Ratio of drug transport assessed as OCTN2 transporter mediated effective permeability in rat duodenum at 76 uM in absence of L-carnitine to drug transport assessed as OCTN2 transporter mediated effective permeability in rat duodenum at 76 uM in presence of L-carnitine
Assay data:2 Tested
Ratio of drug transport assessed as OCTN2 transporter mediated effective permeability in rat jejunum at 76 uM in absence of L-carnitine to drug transport assessed as OCTN2 transporter mediated effective permeability in rat jejunum at 76 uM in presence of L-carnitine
Drug transport assessed as OCTN2 transporter mediated cell permeability in human Caco2 cells across apical to basolateral side at 25 uM in presence of palmitoyl-L-carnitine by UPLC-MS/MS method
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ratio of drug transport assessed as OCTN2 transporter mediated cell permeability in human Caco2 cells at 25 uM in absence of L-carnitine to drug transport assessed as OCTN2 transporter mediated cell permeability in human Caco2 cells at 25 uM in presence of L-carnitine
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 100 uM in presence of palmitoyl-L-carnitine
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 100 uM after 10 mins in presence of L-carnitine by UPLC-MS/MS method
Ratio of drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 100 uM in absence of L-carnitine to drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 100 uM in presence of L-carnitine
Drug transport in OCTN2 (unknown origin) expressing HEK293 cells assessed as transporter-mediated drug uptake at 25 uM after 15 mins by UPLC-MS/MS method
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 1 to 800 uM at 4 degC incubated for 10 mins
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 1 to 800 uM at 37 degC incubated for 10 mins
Assay data:2 Active, 4 Tested
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 1 to 800 uM in presence of Na+
Ratio of drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 1 to 800 uM in presence of Na+ to drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 1 to 800 uM in presence of N-methyl-D-glucamine
Drug transport assessed as OCTN2 transporter mediated drug uptake in human Caco2 cells at 25 uM in presence of ENT1 inhibitor dipyridamole after 45 mins by UPLC-MS/MS analysis
Assay data:2 Active, 2 Tested
Inhibition of OCTN2 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]carnitine substrate uptake at 1500 uM by liquid scintillation counting
Inhibition of OCTN1 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]ergothioneine substrate uptake at 1500 uM by liquid scintillation counting
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