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Binding affinity to wild type rat ASIC1 at binding pocket D237azF transfected in HEK293 cells at 3 uM at pH 50 incubated for 40 hrs by patch clamp assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells assessed as increase in ASIC1 current at 3 uM incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 at binding pocket D345azF transfected in HEK293 cells at 3 uM at pH 7.2 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells at 3 uM at pH 5 incubated for 40 hrs by patch clamp assay relative to control
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells assessed as reduction in proton sensitivity at 3 uM at pH 50 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 at binding pocket D345azF transfected in HEK293 cells at 3 uM incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells assessed as reduction in proton sensitivity at 3 uM at pH 0.3 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to rat ASIC1 transfected in HEK293 cells assessed as reduction in proton sensitivity at 3 uM at pH 50 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells at 3 uM at pH 50 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells at 3 uM at pH 7.2 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells at 3 uM at pH 6 incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to wild type rat ASIC1 transfected in HEK293 cells at 3 uM incubated for 40 hrs by patch clamp assay relative to control
Binding affinity to rat ASIC1 assessed as increase in ASIC1 current at 2.5 uM by two electrode voltage-clamp assay relative to control
Modulation of rat ASIC1 by two electrode voltage-clamp assay
Inhibition of ASIC1b (unknown origin) at 3 uM relative to control
Inhibition of ASIC1a (unknown origin) at 3 uM relative to control
Inhibition of ASIC1a in acid stimulated-human Neural Progenitor Cells assessed as reduction in current amplitude at pH 6.5 at 10 uM measured for 5 mins with acid stimulation for every 2 mins by electrophysiology (Rvb = 92.41 +/- 33.66 pA)
Inhibition of ASIC1a in acid stimulated-human Neural Progenitor Cells assessed as reduction in current amplitude at pH 6.5 at 10 uM measured for 5 mins with acid stimulation for every 2 mins by electrophysiology relative to control
Inhibition of mouse ASIC2a expressed in genetically engineered-CHO-K1 cells at 10 uM preincubated for 10 mins at pH 7.4 followed by cell stimulation with proton injection at pH 6.5 by electro-chromic fluorescence voltage sensor-based assay relative to control
Assay data:12 Tested
Inhibition of mouse ASIC1a expressed in genetically engineered-CHO-K1 cells at 10 uM preincubated for 10 mins at pH 7.4 followed by cell stimulation with proton injection at pH 6.5 by electro-chromic fluorescence voltage sensor-based assay relative to control
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