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Modulation of GATA4/NKX2-5 protein-protein interaction in neonatal Wistar rat cardiomyocytes harboring -534/+4 bp rat BNP proximal promoter assessed as reduction in hypertrophic response at 30 preincubated for 1 hr followed by hypertrophic agonist endothelin-1 and measured after 24 hrs by luminescence method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of GATA4/NKX2-5 protein-protein interaction in neonatal Wistar rat cardiomyocytes harboring -534/+4 bp rat BNP proximal promoter assessed as reduction in BNP-promoter driven activity at 10 to 30 preincubated for 1 hr followed by hypertrophic agonist endothelin-1 and measured after 24 hrs by luminescence method
Modulation of GATA4/NKX2-5 protein-protein interaction in neonatal Wistar rat cardiomyocytes harboring -534/+4 bp rat BNP proximal promoter assessed as increase in BNP-promoter driven activity at 10 to 30 preincubated for 1 hr followed by hypertrophic agonist endothelin-1 and measured after 24 hrs by luminescence method
Assay data:2 Active, 2 Tested
Enhancement of mouse NKX2-5 expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as protein-induced transcriptional activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mouse GATA4/mouse NKX2-5 protein-protein interaction expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as transcriptional synergy at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Enhancement of mouse GATA4/mouse NKX2-5 protein-protein interaction expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as transcriptional synergy at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Modulation of mouse NKX2-5 expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as protein-induced transcriptional activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:97 Tested
Modulation of mouse GATA4/mouse NKX2-5 protein-protein interaction expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as transcriptional synergy at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:99 Tested
Inhibition of mouse NKX2-5 expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as protein-induced transcriptional activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control
Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of BNP at 100 uM after 24 hrs by real-time PCR analysis relative to control
Assay data:1 Tested
Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of ANP at 100 uM after 24 hrs by real-time PCR analysis relative to control
Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in endothelin-1 induced mRNA level of BNP at 20 uM preincubated for 1 hr followed by endothelin-1 addition measured after 23 hrs by real-time PCR analysis relative to control
Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of BNP at 20 uM after 24 hrs by real-time PCR analysis relative to control
Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of ANP at 20 uM after 24 hrs by real-time PCR analysis relative to control
Inhibition of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as decrease in endothelin-1 induced mRNA level of BNP at 20 uM preincubated for 1 hr followed by endothelin-1 addition measured after 23 hrs by real-time PCR analysis
Inhibition of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as decrease in endothelin-1 induced mRNA level of ANP at 20 uM preincubated for 1 hr followed by endothelin-1 addition measured after 23 hrs by real-time PCR analysis
Assay data:4 Active, 4 Tested
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells at 50 uM measured after 30 hrs by dual luciferase reporter gene assay
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells at 20 uM measured after 30 hrs by dual luciferase reporter gene assay
Inhibition of mouse GATA4/FLAG-tagged NKX2-5 interaction expressed in African green monkey COS-1 cells at 100 uM by coimmunoprecipitation method
Activation of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells at 10 uM measured after 30 hrs by dual luciferase reporter gene assay
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