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Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human IP receptor expressed in rat C6 cells assessed as binding constant
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human IP receptor assessed as binding constant
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Homogeneous Time-Resolved Fluorescence (HTRF) Assay from US Patent US11098034: "Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
HTRF assay from US Patent US10793529: "Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators"
Homogeneous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement from US Patent US10668033: "Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto"
Cell Based Assay from US Patent US9422273: "Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response"
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
IP Receptor Filter Binding Assay and cAMP Assay from Article 10.1016/j.bmcl.2006.12.025: "Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists."
Assay data:17 Active, 7 Activity ≤ 1 µM, 17 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement from US Patent US10214518: "Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
IP (PGI2) Eurofins-Panlabs radioligand binding assay
SummaryRelated BioAssays by Target
Prostanoid IP Eurofins-Panlabs radioligand binding assay
Assay data:3 Tested
PRESTO-Tango GPCRome screening (PTGIR)
Binding assay (PTGIR)
PGI2/H Cerep selectivity data (BI)
PGI2 CEREP ligand profiling
Prostaglandin I2 receptor CEREP ligand profiling
PGI2 (h) Ligand binding assay
hIP1 Cerep panel
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