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Inhibition of human recombinant full length DDX3X helicase activity expressed in Escherichia coli using dsRNA as substrate measured after 40 mins by FRET assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant DDX3X (unknown origin) helicase activity using 6-FAM-labeled dsRNA as substrate incubated for 30 mins by fluorescence based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant DDX3X (unknown origin) helicase activity using dsRNA as substrate incubated for 40 mins by FRET assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of DDX3X (unknown origin) helicase activity
Assay data:8 Active, 6 Activity ≤ 1 µM, 11 Tested
Binding affinity to His-tagged full-length recombinant human DDX3X expressed in Escherichia coli assessed as inhibition constant in presence of ATP by ADP-Glo kinase assay
Assay data:2 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to DDX3X (unknown origin) assessed as inhibition constant
Assay data:25 Active, 12 Activity ≤ 1 µM, 31 Tested
Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay
Assay data:17 Active, 11 Activity ≤ 1 µM, 26 Tested
Induction of DDX3X recruitment in human HuH7 cells infected with 100 TCID50 of Dengue virus serotype 2 New Guinea C assessed as increase in DDX3X expression in perinuclear region at 20 uM measured at 48 to 72 hrs post-infection by Alexa fluor 488 dye based confocal microscopy
Assay data:1 Active, 1 Tested
Induction of DDX3X recruitment in human HuH7 cells infected with 100 TCID50 of Dengue virus serotype 2 New Guinea C assessed as colocalization of DDX3X in perinuclear region at 20 uM measured at 6 to 24 hrs post-infection by Alexa fluor 488 dye based confocal microscopy
Inhibition of recombinant full length human His-tagged DDX3X expressed in Escherichia coli using dsRNA as substrate measured after 40 mins in presence of ATP by FRET assay
Assay data:22 Active, 16 Activity ≤ 1 µM, 24 Tested
Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Competitive inhibition of human full length His-tagged DDX3X helicase activity expressed in Escherichia coli using FAM-labeled double stranded RNA as substrate at 0.1 uM after 40 mins by fluorescence assay
Assay data:1 Tested
Competitive inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using 0.1 uM FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control
Competitive inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using 0.024 uM FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control
Assay data:21 Tested
Binding affinity to DDX3X in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Inhibition of DDX3 (unknown origin) preincubated for 10 mins followed by ATP addition by malachite green dye-based assay
Assay data:2 Tested
Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.
Assay data:1 Active, 1 Activity ≤ 1 µM, 243 Tested
Binding affinity to DDX3 in mouse embryonic fibroblasts by Western blot method
Competitive inhibition of human recombinant DDX3 expressed in Escherichia coli using 100 nM double strand 18/36mer RNA substrate by PAGE analysis
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