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Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Assay data:5 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Induction of redissolving of aggregated alpha-crystallin B R120G mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Assay data:1 Active, 2 Tested
Induction of redissolving of aggregated alpha-crystallin B R120G mutant (unknown origin) incubated for 24 hrs by ThT-fluorescence based assay
Assay data:1 Active, 1 Tested
Induction of redissolving of aggregated alpha-crystallin B R120G mutant (unknown origin) at 200 uM incubated for 24 hrs by ThT-fluorescence based assay
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Assay data:5 Active, 10 Tested
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Assay data:39 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells at 0.4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Binding affinity to CRYAB (unknown origin) assessed as reduction in CRYAB-VEGFA protein interaction
Assay data:1 Tested
SummaryRelated BioAssays by Target
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