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Induction of HSF-1 (unknown origin) degradation assessed as ATPase activity by colorimetric assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Arrayscan Assay from US Patent US9701664: "Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1"
Assay data:44 Active, 29 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Titre Blue Assay from US Patent US9701664: "Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1"
Assay data:117 Active, 1 Activity ≤ 1 nM, 112 Activity ≤ 1 µM, 117 Tested
Cell-Based ELISA (Cellisa) Assay from US Patent US9701664: "Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1"
Assay data:202 Active, 188 Activity ≤ 1 µM, 202 Tested
Induction of HSF-1 degradation in human HT-29 cells at 0.5 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Hsf1 in human HEK293 cells transfected with Hsp70.1pr-luc plasmid at 1 uM incubated for 24 hrs by luciferase reporter gene based luminescence assay
Assay data:4 Active, 4 Tested
Activation of Hsf1 in human MSC-NEU cells assessed as increase in HSP70 substrate-binding chaperone activity at 1 uM incubated for 24 hrs by protein-protein interaction assay relative to control
Assay data:4 Tested
Activation of Hsf1 in human MSC-NEU cells assessed as induction of HSP90 accumulation at 1 uM incubated for 24 hrs by Western blotting analysis relative to control
Activation of Hsf1 in human MSC-NEU cells assessed as induction of HSP70 accumulation at 1 uM incubated for 24 hrs by Western blotting analysis relative to control
Activation of HSF-1 in human HG23 cells transfected with human norovirus after 72 hrs by dual-luciferase reporter gene assay
Assay data:1 Active, 2 Tested
Activation of HSF-1 in human HG23 cells transfected with human norovirus at 10 uM after 72 hrs by dual-luciferase reporter gene assay
Inhibition of NVP-AUY922-induced HSF-1 phosphorylation in human INA-6 cells at 10 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by Western blot method
Inhibition of NVP-AUY922-induced HSF-1 phosphorylation at S326 residue in human INA-6 cells at 25 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by Western blotting method
Inhibition of NVP-AUY922-induced HSF-1 phosphorylation at S326 residue in human INA-6 cells at 50 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by Western blot method
Assay data:11 Active, 11 Tested
Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP27 induction at 10 to 1000 nM preincubated for 1 hr followed by 17-AAG addition measured after 18 hrs by ELISA
Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addition measured after 18 hrs by ELISA
Assay data:9 Active, 8 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSPA1A mRNA level preincubated for 1 hr followed by 17-AAG addition measured after 6 hrs by Western blot method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addition measured after 18 hrs by ELISA
Disruption of full length human HSF1 trimer structure at 20 uM after 30 mins by Western blot analysis
Disruption of full length human HSF1 trimer structure at 20 uM after 30 mins by SDS-PAGE analysis
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