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Transporter, GABA Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells (PubChem AID: 1794824)
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Substrate uptake by the Sodium- and Chloride-Dependent BetaineTransporter (BGT-1, SLC6A12) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A12 cells (PubChem AID: 1794822)
Inhibition of mouse GAT-4 assessed as inhibition of [3H]GABA uptake by liquid scintillation counter method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human BGT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
Inhibition of human GAT-3 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
Inhibition of mouse GAT-2 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptake
Assay data:2 Tested
Antagonist activity at human GAT3 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Antagonist activity at human BGT1 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Antagonist activity at human GAT2 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Membrane potential based assay for SLC6A6 using HEK-293 SLC6A6 OE cells
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Membrane potential based assay for SLC6A12 using HEK-293 SLC6A12 OE cells
Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake at 100 uM measured after 40 mins by LC-ESI-MS/MS analysis
Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake at 100 uM measured after 40 mins by LC-ESI-MS/MS analysis
Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake at 100 uM measured after 40 mins by LC-ESI-MS/MS analysis
Assay data:3 Tested
Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysis
Assay data:13 Active, 32 Tested
Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysis
Assay data:12 Active, 32 Tested
Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysis
Assay data:9 Active, 30 Tested
Inhibition of human GAT3 expressed in COS-7 cells assessed as reduction in [2H6]GABA uptake preincubated for 25 mins followed by [2H6]GABA addition and measured after 6 mins by LC-MS/MS analysis
Assay data:3 Active, 3 Tested
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