Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Binding affinity to ChemR23 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to ChemR23 in HEK293T cells at 40 to 1000 nM by flow cytometric analysis
Binding affinity to ChemR23 (unknown origin) expressed in HEK293T cells at 40 to 1000 nM by flow cytometric analysis
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
Assay data:33 Active, 37 Activity ≤ 1 µM, 37 Tested
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
Assay data:4 Active, 4 Activity ≤ 1 µM, 9 Tested
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
Antagonist activity against CMKLR1 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CMKLR1 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CMKLR1)
SummaryRelated BioAssays by Target
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
Assay data:38 Active, 35 Activity ≤ 1 µM, 41 Tested
Antagonist activity at human CMKLR1 expressed in CHOK1 cells assessed as inhibition of chemerin-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by chemerin stimulation and measured after 90 to 180 mins by pathhunter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Induction of chemR23 internalization in in human CAL1 cells at 3 uM incubated for 30 mins at 4 degC by flow cytometric analysis
Assay data:2 Tested
Induction of chemR23 internalization in in human CAL1 cells at 10 uM incubated for 30 mins at 4 degC by flow cytometric analysis
Induction of chemR23 internalization in in human CAL1 cells at 3 uM incubated for 30 mins at 37 degC by flow cytometric analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of chemR23 internalization in in human CAL1 cells at 10 uM incubated for 30 mins at 37 degC by flow cytometric analysis
Assay data:1 Active, 1 Tested
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
Assay data:6 Active, 4 Activity ≤ 1 µM, 9 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on