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hEP4 cAMP Assay from US Patent US12011444: "N-substituted indole derivatives as PGE2 receptor modulators"
Assay data:1074 Active, 7 Activity ≤ 1 nM, 1074 Activity ≤ 1 µM, 1074 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellular cAMP measured after 3 hrs by TR FRET based assay
Binding affinity to EP4 receptor (unknown origin) assessed as binding constant
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human EP4 receptor expressed in HEK cells assessed as binding constant by Schild regression analysis
Binding affinity to EP4 receptor in human mast cell assessed as inhibition constant
Binding affinity to human EP4 receptor expressed in CHO cells assessed as inhibition constant
hEP4 cAMP Assay from US Patent US11839613: "Pyrimidine derivatives as PGE2 receptor modulators"
Assay data:456 Active, 4 Activity ≤ 1 nM, 450 Activity ≤ 1 µM, 456 Tested
Selectivity interaction (Eurofins-Panlabs radioligand binding assay ) EUB0000307b PTGER4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Eurofins-Panlabs radioligand binding assay ) EUB0000293b PTGER4
SummaryRelated BioAssays by Target
Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as rightward shift in PGE2 concentration response curve without affecting maximal effect up to 1000 nM preincubated for 30 mins followed by PEG2 addition by GloSensor cAMP assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 mins followed by PEG2 addition by Schild plot based GloSensor cAMP assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human EP4 receptor expressed in CHO cells coexpressing tTA-dependent luciferase reporter and beta arrestin 2-TEV assessed as reduction in beta-arrestin recruitment preincubated for 30 mins followed by PEG2 addition and measured after 12 hrs by Tango assay
Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 mins followed by PEG2 addition by GloSensor cAMP assay
Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 10 Tested
Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assay
Assay data:38 Active, 3 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 43 Tested
PEP4_HU Eurofins SafetyScreen44 (BI)
Binding affinity to human EP4 receptor assessed as inhibition constant
EP4 Antagonistic Activity Measurement from US Patent US11479550: "EP4 antagonist"
Assay data:38 Active, 4 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 38 Tested
Detection of the Antagonism of the Human Prostaglandin D Receptor Signal from US Patent US10730856: "Benzimidazole derivatives as EP4 ligands"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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