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Inhibition of human MLK2 at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
MLK2 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
MLK2(h) Kinase panel
Inhibition of MLK2 (unknown origin) at 1 uM
Mixed-Lineage Kinase Assay from Article 10.1021/jm8005838: "Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models."
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
Assay data:16 Active, 16 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
KinomeScan assay: inhibition of MLK2
Assay data:108 Tested
MLK2(h) Eurofins kinase panel
MAP3K10 ProQinase selectivity panel
MAP3K10 (MLK2) Kinase screen
MAP3K10 Invitrogen selectivity data (BI)
MLK2(h) Eurofins Kinase panel
MLK2(h) Millipore kinase panel
MAP3K10 Invitrogen Lab (UK) kinase screen (BI)
MLK2 Kinase panel
Inhibition of MLK2 (unknown origin) at 0.5 uM relative to control
Inhibition of MAP3K10 (unknown origin) assessed as residual activity measured at 1 uM
Assay data:3 Tested
Inhibition of MAP3K10 (unknown origin) assessed as residual activity at 1 uM
Assay data:2 Tested
Inhibition of human MLK2 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human MLK2 assessed as percent of control at 50000 nM by qPCR analysis relative to control
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