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Inhibition of PRMT3 (unknown origin) incubated for 15 mins measured after 60 min by AlphaLISA assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b PRMT3
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (ITC) EUB0000197b PRMT3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl PRMT3
Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b PRMT3
Selectivity interaction (HMT panel) EUB0000209b PRMT3
Selectivity interaction (HMT panel) EUB0000194b PRMT3
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b PRMT3
Affinity Biochemical interaction (SPR) EUB0000197b PRMT3
Affinity Biochemical interaction (Scintillation proximity assay (SPA) ) EUB0000034d PRMT3
Affinity On-target Cellular interaction (Western Blot assay (measuring H4R3me2a levels in HEK293 cells co-transfected with FLAG tagged PRMT3 (wt))) EUB0000197b PRMT3
Affinity On-target Cellular interaction (Western Blot (inhibition of PRMT3 methyltransferase activity in MCF7 cells)) EUB0000034d PRMT3
Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay
Assay data:1 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N-terminal His-tagged PRMT3 (2 to 531 residues)(unknown origin) expressed in Escherichia coli at 1 uM using 3H-SAM as a substrate relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant N-terminal His-tagged PRMT3 (2 to 531 residues) expressed in Escherichia coli at 50 uM in presence of [3H]-SAM by Hotspot assay relative to control
Inhibition of human recombinant N-terminal His-tagged PRMT3 (2 to 531 residues) expressed in Escherichia coli at 10 uM in presence of [3H]-SAM by Hotspot assay
Inhibition of PRMT3 (unknown origin) by scintillation proximity assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PRMT3 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Enzymatic Assay from Article 10.1111/cbdd.12881: "Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations."
Assay data:5 Active, 1 Activity ≤ 1 µM, 13 Tested
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