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Inhibition of TGF-beta induced Smad2/3 signaling in human HepG2 cells harboring pRL-EF1alpha, (CAGA)9x-MLP-Luc plasmid assessed as luciferase activity incubated for 24 hrs by Promega reporter rene assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1 induced Smad3 phosphorylation in mouse pulmonary fibroblast cells at 10 to 40 uM incubated for 0.5 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1/Smad3 signalling in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene incubated for 18 hrs by luciferase based analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1/Smad3 signalling in in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene assessed as suppression ratio at 10 uM incubated for 18 hrs by luciferase based analysis
Inhibition of TGF-beta1/Smad3 signalling in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene assessed as suppressive ratio at 10 uM incubated for 18 hrs by luciferase based analysis relative to control
Assay data:36 Tested
Inhibition of TGF-beta1-induced Smad2/3 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TGF-beta1 induced SMAD3 phosphorylation in human LX2 cells by Western blot analysis
Assay data:2 Tested
Inhibition of TGF-beta1 induced SMAD2/3 phosphorylation in human LX2 cells at 3 to 10 uM incubated for 24 hrs by Western blot analysis
Inhibition of TGF-beta induced SMAD3 phosphorylation in wild-type mouse CD4 positive T cells at 0.5 to 5 uM by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of TGF-beta induced SMAD3 phosphorylation in rat NRK-49F cells at 20 to 40 uM pretreated with compound for 1 to 2 hrs followed by TGF-beta stimulation for 1 hr by Western blot analysis
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 5 uM by CAGA-based luciferase reporter assay relative to control
Assay data:26 Tested
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 10 uM by CAGA-based luciferase reporter assay relative to control
Assay data:27 Tested
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase by CAGA-based luciferase reporter assay
Inhibition of TGF-beta induced SMAD3 phosphorylation in human A549 cells at 5 to 10 uM pretreated with compound for 2 hrs followed by TGF-beta stimulation by Western blot analysis
Inhibition of TGF beta1/Smad3 signaling in mouse NIH/3T3 cells harboring CAGA promoter incubated for 18 hrs in presence of TGF-beta1 by luciferase reporter gene assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of TGF beta1/Smad3 signaling in mouse NIH/3T3 cells harboring CAGA promoter at 10 uM incubated for 18 hrs in presence of TGF-beta1 by luciferase reporter gene assay relative to control
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced Smad3 phosphorylation at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced alpha-SMA expression in at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced COL1A1 expression in at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Induction of Smad1/5/8 phosphorylation in mouse MC3T3-E1 cells assessed as ratio of phosphorylated Smad1/5/8 to actin beta protein level at 30 uM measured after 30 mins by Western blot analysis relative to control
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