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Inhibition of recombinant human BAX expressed in Escherichia coli BL21 (DE3) assessed as inhibition of liposome permeabilization and measured for 2 hrs by fluorescence analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human BAX (1 to 92 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubated for 10 mins by microscale thermophoresis analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human full length GST-tagged BAX expressed in Escherichia coli BL21 (DE3) measured after 20 mins by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to BAX (unknown origin) assessed as dissociation constant by ITC analysis
Assay data:1 Tested
Binding affinity to recombinant human BAX assessed as dissociation constant by ITC analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of Bak BH3 domain peptide from human Bax by competitive fluorescence polarization assay
Activation of Bax in human MDA-MB-231 cells assessed as increase in Bax insertion into mitochondria at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Activation of Bax in human MDA-MB-231 cells assessed as increase in cleaved caspase 3 level at 1 to 10 uM incubated for 48 hrs by Western blot analysis
Activation of Bax in human MDA-MB-231 cells assessed as increase in cleaved PARP level at 1 to 10 uM incubated for 48 hrs by Western blot analysis
Activation of Bax in human MDA-MB-231 cells assessed as increase in cytochrome C release into cytosol incubated for 24 hrs by Western blot analysis
Activation of Bax in human MDA-MB-231 cells assessed as increase in Bax insertion into mitochondria incubated for 24 hrs by Western blot analysis
Activation of BAX (unknown origin)
Binding affinity to recombinant human full length His-tagged BAX expressed in Escherichia coli BL21 (DE3) cells preincubated for 30 min followed by FITC-BIM addition and measured after 20 mins by fluorescence polarization assay
Assay data:15 Active, 13 Activity ≤ 1 µM, 16 Tested
Activation of BAX in human HeLa cells assessed as confirmation activation at Bax6A7 after 6 to 12 hrs by immunoprecipitation assay
Activation of Bax in human SMMC7721 cells
Displacement of fluorescent Bak BH3 peptide domain from human recombinant Bax by competition fluorescence polarization assay
Activation of Bax in triple-negative human MDA-MB-231 cells assessed as increase in cytosolic cytochrome C level at 5 uM incubated for 48 hrs by Western blot analysis
Activation of Bax in ER-positive human MCF7 cells assessed as increase in cytosolic cytochrome C level at 5 uM incubated for 48 hrs by Western blot analysis
Activation of Bax in ER-positive human MCF7 cells assessed as increase in active Bax 6A7 isoform protein level at 5 uM incubated upto 48 hrs by Western blot analysis
Activation of Bax in ER-positive human MCF7 cells assessed as reduction in Bax phosphorylation at Ser184 at 5 uM incubated upto 48 hrs by Western blotting analysis
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