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Inhibition of MCP-1 in LPS-stimulated human whole blood incubate for 24 hrs by immuno assay
Assay data:29 Active, 23 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human CCL2 assessed as off-rate constant incubated for 3 mins by surface plasmon resonance analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human CCL2 assessed as on-rate constant incubated for 3 mins by surface plasmon resonance analysis
Binding affinity to human CCL2 assessed as dissociation constant incubated for 3 mins by surface plasmon resonance analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human CCL2 at 100 uM by glycan microarray analysis
Assay data:12 Tested
Binding affinity to human CCL7 at 100 uM by glycan microarray analysis
LPS-PBMC assay (MCP-1)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In vitro inhibition of MCP-1 in Lipopolysaccharide-stimulated human whole blood
Binding affinity to CCL2 (unknown origin) assessed as inhibition of CXCL12 -induced increase in intracellular calcium level in EGFP-tagged CCR2 expressing HEK cells at 10 uM
Binding affinity to human recombinant CCL2 by surface plasmon resonance assay
Assay data:3 Tested
Binding affinity to human recombinant CCL11 by surface plasmon resonance assay
Inhibition of CCL2 in human THP1 cells assessed as reduction of cell migration at 50 uM after 3 hrs
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of CCL2 in human THP1 cells assessed as reduction of cell migration at 100 uM after 3 hrs
Assay data:2 Active, 2 Tested
Inhibition of CCL2 in human THP1 cells assessed as reduction of cell migration into TNFalpha/IFNgamma-stimulated HMEC-1 cells at 50 uM after 4 hrs
Assay data:2 Tested
SummaryRelated BioAssays by Target
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