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Fluorescence Polarization TTR Tetramer Binding Assay from US Patent US20240150297: "NOVEL COMPOUNDS COMPRISING A NEW CLASS OF TRANSTHYRETIN LIGANDS FOR TREATMENT OF COMMON AGE-RELATED COMORBIDITIES"
Assay data:15 Active, 13 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as change in entropy by ITC assay
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as change in enthalpy by ITC assay
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as gibbs free energy change by ITC assay
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of acid mediated TTR V30M mutant aggregation (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by acid stimulation and measured after 96 hrs by fluorescence spectrophotometer analysis
Assay data:11 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of (E)-S-phenyl 3(4-hydroxy-3,5-dimethylstyryl)benzothioate from human plasma TTR at 20 uM incubated for 6 hrs by fluorescence based assay
Assay data:5 Active, 6 Tested
Displacement of [125I]-T4 from human recombinant TTR expressed in Escherichia coli BL21(DE3) Star by gamma spectrometric analysis
Assay data:16 Active, 16 Tested
Binding affinity to human TTR incubated for 20 mins by fluorescence polarization assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to human serum TTR assessed as target occupancy incubated for 6 hrs by fluorescence polarization assay
Assay data:4 Tested
Inhibition of urea-induced Transthyretin denaturation in human plasma preincubated for 1 hr followed by urea addition by Western blot analysis
Assay data:2 Active, 5 Tested
Inhibition of Transthyretin V30M mutant (unknown origin) assessed as acid mediated fibril formation at 1.8 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:5 Tested
Inhibition of Transthyretin V30M mutant (unknown origin) assessed as acid mediated fibril formation at 3.6 uM measured after 72 hrs by UV-vis spectrophotometry
Inhibition of wild-type Transthyretin (unknown origin) expressed in Escherichia coli expression system assessed as acid mediated fibril formation at 3.6 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:9 Tested
Inhibition of wild-type Transthyretin (unknown origin) expressed in Escherichia coli expression system assessed as acid mediated fibril formation at 7.2 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:10 Tested
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as change in entropy by ITC analysis
Assay data:1 Tested
Binding affinity to first binding site of wild type TTR (unknown origin) assessed as change in entropy by ITC analysis
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as change in enthalpy by ITC analysis
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysis
Binding affinity to first binding site of wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysis
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