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Cognitive activity in ketamine induced rat model assessed as reduction in number of trial at 3.75 mg/kg by attentional set shifting task analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Cognitive activity in ketamine induced rat model assessed as reduction in number of trial at 0.75 mg/kg by attentional set shifting task analysis
Cognitive activity in ketamine induced rat model assessed as reduction in number of trial at 3 mg/kg by attentional set shifting task analysis
Cognitive activity in ketamine induced rat model assessed as reduction in number of trial at 1 mg/kg by attentional set shifting task analysis
Cognitive activity in ketamine induced rat model assessed as amelioration in deficits in extra-dimensional set-shifting by attentional set shifting task analysis
Assay data:1 Tested
SummaryPubMed Citation
Cognitive activity in scopolamine induced amnesia mouse model assessed as prevention in memory impairment by measuring time spent in the open arm upto 10 mg/ml pretreated with compound for 10 mins followed by scopolamine addition by elevated plus maze test
AUClast in mouse brain at 10 mg/kg, sc
Assay data:2 Tested
Cmax in mouse brain at 10 mg/kg, sc
Tmax in mouse brain at 10 mg/kg, sc
AUClast in mouse plasma at 10 mg/kg, sc
Cmax in mouse plasma at 10 mg/kg, sc
Tmax in mouse plasma at 10 mg/kg, sc
Inhibition of CYP2C19 (unknown origin)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP2C9 (unknown origin)
Assay data:1 Active, 2 Tested
Inhibition of CYP2B6 (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 (unknown origin)
Inhibition of hERG by manual patch clamp method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Efflux ratio of permeability from apical to basolateral side over basolateral to apical side in human Caco-2 cells
Permeability across apical to basolateral side in human Caco-2 cells
Permeability of the compound by PAMPA method
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