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Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as reduction in bleeding with normal shaped alveoli at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as clear boundaries between white and red pulps in spleen at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as glomerulus and renal tubules with normal shape in kidney at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as clear boundaries between hepatic cell cords in liver at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Binding affinity to eukaryotic cell membrane mimic DOPC/Cholesterol (3:1) large unilamellar vesicles assessed as calcein leakage measured after 30 mins fluorescence based assay
Assay data:1 Active, 2 Tested
Induction of cell membrane disruption in Escherichia coli assessed as increase in fluorescence intensity at 1 times MIC measured after 60 mins by PI staining based flow cytometric analysis (Rvb = 0.1%)
Assay data:1 Tested
SummaryPubMed Citation
Bactericidal activity against Staphylococcus aureus assessed as decrease in cell survival at 1XMIC measured after 24 hrs by colony counting assay
Bactericidal activity against Escherichia coli assessed as decrease in cell survival at 1XMIC measured after 24 hrs by colony counting assay
Bactericidal activity against Staphylococcus aureus assessed as decrease in cell survival at 0.5XMIC measured after 24 hrs by colony counting assay
Bactericidal activity against Escherichia coli assessed as decrease in cell survival at 0.5XMIC measured after 24 hrs by colony counting assay
Induction of cell membrane disruption in Staphylococcus aureus assessed as cell morphological damage at 20 uM incubated for 1 hr by scanning electron microscopy
Induction of cell membrane disruption in Escherichia coli assessed as wrinkled cells at 20 uM incubated for 1 hr by scanning electron microscopy
Binding affinity to bacterial inner membrane mimic DOPE/DOPG (3:1) large unilamellar vesicles assessed as calcein leakage measured after 30 mins fluorescence based assay
Assay data:2 Active, 2 Tested
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as reduction in inflammatory cell infiltration in lung at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as reduction in inflammatory cell infiltration in spleen at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as reduction in inflammatory cell infiltration in kidney at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Escherichia coli ATCC 8739 assessed as inhibition of bacterial growth measured after 17 passages by turbidity based analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as reduction in inflammatory cell infiltration in liver at 10 mg/kg, ip administered for 12 hrs by Hematoxylin-Eosin staining based microscopic analysis
Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as inhibition of bacterial growth measured after 17 passages by turbidity based analysis
Antibacterial activity against Escherichia coli ATCC 8739 infected in C57BL/6 mouse peritonitis sepsis model assessed as bacterial load in lung at 10 mg/kg, ip administered for 12 hrs (Rvb = 5.47 +/-0.73 logCFU/gm)
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