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Summary of the probe development efforts to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5)
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against human M3
Assay data:5 Tested
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5)
Assay data:699 Active, 364131 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5)
Assay data:1081 Active, 364131 Tested
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5)
Assay data:2140 Active, 364131 Tested
Discovery of Novel Negative Allosteric Modulators (NAM) of Muscarinic Receptor M5: Single Point Assay
Assay data:42 Active, 150 Tested
Discovery of Novel Negative Allosteric Modulators (NAM) of Muscarinic Receptor M5: CRC Assay
Assay data:32 Active, 3 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M2
Assay data:6 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1
Assay data:5 Active, 6 Tested
Discovery of Novel Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against human M1
Discovery of Novel Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against human M2
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Single Point Assay
Assay data:53 Active, 130 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M4
Assay data:11 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Confirmatory Assay
Assay data:46 Active, 15 Activity ≤ 1 µM, 79 Tested
Development of the first CNS penetrant Muscarinic 5 (M5) Positive Allosteric Modulator based on a novel non-isatin core
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against RAT M5
Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested
Discovery of Novel Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against human M4
Discovery of Novel Antagonists of Muscarinic Receptor M5: Single Point Assay
Assay data:4 Active, 61 Tested
Discovery of Novel Antagonists of Muscarinic Receptor M5: Counterscreen against human M1
Discovery of Novel Antagonists of Muscarinic Receptor M5: Counterscreen against human M2
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