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Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: BioAssay Summary, ML 353
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Optimization of novel mGluR5 positive allosteric modulators (PAM)s
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
mGluR5_3H_methoxyPEPy_Binding
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
ML353 Eurofin Panel Assay for mGlu5 SAM Inhibitor (Probe Compound)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy
Assay data:23 Active, 17 Activity ≤ 1 µM, 36 Tested
rmGluR3_Thallium_Fold_Shift (GIRK)
Assay data:2 Tested
hmGluR6_Thallium_Fold_Shift (GIRK)
rmGluR7_Thallium_Fold_Shift (GIRK)
rmGluR8_Thallium_Fold_Shift (GIRK)
rmGluR2_Thallium_Fold_Shift (GIRK)
rmGluR4_Thallium_Fold_Shift (GIRK)
rmGluR5_Calcium_Fold_Shift
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
rmGluR1_Calcium_Fold_Shift
hmGluR5_Calcium_Fold_Shift
ML254 and ML273 Competition in Radioligand Binding assays (Riserca)
Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay)
Assay data:16 Active, 6 Activity ≤ 1 µM, 32 Tested
Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (binding_assay)
Assay data:4 Tested
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: rat mGlu2 selectivity Assay
Assay data:1 Tested
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: rat mGlu8 selectivity Assay
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay
Assay data:11 Active, 18 Activity ≤ 1 µM, 19 Tested
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