Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Fold-shift Selectivity at rM1
Assay data:2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Human M3 PAM Extended Characterization CounterScreen (CRC)
Assay data:9 Tested
Human M1 PAM Extended Characterization CounterScreen (CRC)
Assay data:1 Active, 1 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Chemical optimization of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series
Assay data:34 Active, 27 Activity ≤ 1 µM, 37 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Foldshift of Acetylcholine with human M4
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Fold-shift Selectivity at rM4
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Foldshift of Acetylcholine
Assay data:22 Active, 23 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM): NMS Competition at rM4
Assay data:2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM): Analog Dose Response with rM4
Assay data:4 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Human M2 PAM Extended Characterization CounterScreen (CRC)
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Fold-shift Selectivity with hM2
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Foldshift Selectivity with hM3
Assay data:2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 6 Tested
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Fold-shift Selectivity at hM5
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
Assay data:32 Active, 17 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 39 Tested
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator: Ancillary Activity
Assay data:2 Tested
Discovery of Novel Allosteric Agonists of the M4 Muscarinic Receptor: Confirmation Screen
Assay data:25 Active, 48 Tested
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen
Assay data:1938 Active, 63682 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Discovery of Novel Allosteric Agonists of the M4 Muscarinic Receptor: Primary Screen
Assay data:69 Active, 12369 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (hM2 CounterScreen)
Assay data:1 Active, 1 Activity ≤ 1 µM, 10 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on