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NanoBRET assay (JAK1, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of tubulin polymerization (unknown origin) by fluorescence assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins followed by GTP addition and measured for 20 mins by spectrophotometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of JAK1 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in whole blood pERK level incubated for 4 hrs by HTRF assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in pERK level incubated for 4 hrs by HTRF assay
Inhibition of KRAS G12C mutant (unknown origin) assessed as inhibition of SOS1 mediated nucleotide exchange incubated for 2 hrs in presence of GppNHp by fluorescence based analysis
Protac activity at VHL/KRAS G12D in human ASPC1 cells assessed as induction of KRAS G12D protein degradation at 1 uM incubated for 24 hrs by luminescence based analysis relative to control
Assay data:6 Tested
Induction of microtubule stabilization in human HeLa cells assessed as effect on cellular cytoskeletal network of tubulin at 5 to 10 uM incubated for 4 hrs by Alexa Fluor 488 staining based confocal microscopic analysis
Assay data:2 Active, 2 Tested
Induction of microtubule stabilization (unknown origin) at 1 to 5 uM
Induction of microtubule stabilization (unknown origin) at 0.2 to 5 uM
Induction of microtubule destabilization (unknown origin) at 5 uM
Assay data:1 Tested
Induction of microtubule stabilization (unknown origin) at 5 uM
Inhibition of KRAS G12D mutant in human ASPC1 cells assessed as reduction in ERK1/2 phosphorylation level incubated for 2 hrs by MSD assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal His-tagged GDP-bound KRAS G12D mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS mediated nucleotide exchange preincubated for 2 hrs followed by addition of SOS protein and unlabeled GTP measured after 30 mins by Alphascreen assay
Assay data:12 Active, 4 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of His-tagged KRAS G12D mutant (unknown origin) using biotinylated KRPep-2d as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by LANCE TR-FRET assay
Assay data:12 Active, 7 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of GTP bound KRAS G12D mutant in human GP2d cells assessed as reduction in pERK level incubated for 3 hrs
Assay data:12 Activity ≤ 1 µM, 12 Tested
Inhibition of tubulin polymerization in human HCT-116 cells
Inhibition of tubulin polymerization in human HCT-116 cells at 0.55 uM measured after 1 hr relative to control
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