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Inhibition of NA+/K+ ATPase (unknown origin) activity assessed as inhibition constant
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NA+/K+ ATPase (unknown origin) activity
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ASIC1b (unknown origin) at 3 uM relative to control
Assay data:1 Tested
Inhibition of ASIC1a (unknown origin) at 3 uM relative to control
Inhibition of ASIC1a in acid stimulated-human Neural Progenitor Cells assessed as reduction in current amplitude at pH 6.5 at 10 uM measured for 5 mins with acid stimulation for every 2 mins by electrophysiology (Rvb = 92.41 +/- 33.66 pA)
Inhibition of ASIC1a in acid stimulated-human Neural Progenitor Cells assessed as reduction in current amplitude at pH 6.5 at 10 uM measured for 5 mins with acid stimulation for every 2 mins by electrophysiology relative to control
Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by patch-clamp electrophysiology
Assay data:11 Active, 4 Activity ≤ 1 µM, 11 Tested
Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 by patch-clamp electrophysiology
Inhibition of PI4K2A catalytic domain (unknown origin) assessed as enzyme residual activity incubated for 60 mins using ATP as substrate by ATP-Glo luminescent assay
Assay data:1 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to HSPD1 in human DOHH-2 cells by MS analysis
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.4 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.2 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.1 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.4 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.2 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.1 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Assay data:1 Active, 1 Tested
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells at 50 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Assay data:12 Tested
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 9 Tested
Negative allosteric modulation activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins by Fura-2 AM based fluorescence assay relative to control
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins by Fura-2 AM based fluorescence assay relative to control
Assay data:11 Tested
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