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Binding affinity towards human ESR2 in an in vitro cell free assay measured by fluorescence polarization method
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 287 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Estrogen receptor alpha (unknown origin) at 1 uM by displacement assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Estrogen receptor beta (unknown origin) at 1 uM by displacement assay relative to control
Competitive inhibition of hnRNP M to in human A549 cells at 50 uM by immunoblotting analysis
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Induction of ER-alpha degradation in human T47D cells assessed as decrease in ER-alpha protein expression in presence of autophagy inhibitor, CQ by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of ER-alpha degradation in human T47D cells assessed as decrease in ER-alpha protein expression in presence of autophagy inhibitor, 3-MA of by western blot analysis
Induction of ER-alpha degradation in tamoxifen-resistant human LCC2 cells assessed as decrease in ER-alpha protein expression at 10 uM by western blot analysis
Induction of ER-alpha degradation in human T47D cells overexpressing ER-alpha assessed as decrease in MYC protein expression at 10 uM incubated for 24 hrs by western blot analysis
Induction of ER-alpha degradation in human T47D cells assessed as decrease in MYC protein expression at 1 to 5 uM incubated for 24 hrs by western blot analysis
Induction of ER-alpha degradation in human T47D cells assessed as decrease in MYC protein expression at 10 uM incubated for 24 hrs by western blot analysis
Induction of ER-alpha degradation in human T47D cells assessed as decrease in ER-alpha protein expression in presence of proteasome inhibitor, MG132 by western blot analysis
Induction of ER-alpha degradation in human T47D cells assessed as reduction in ER-alpha stability at 10 uM incubated for 3 to 9 hrs in presence of protein synthesis inhibitor, CHX by CHX chase assay based western blot analysis
Protac activity at VHL/ER alpha in human MCF7 cells assessed as degradation of ER alpha incubated for 6 hrs by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Protac activity at ER/VHL (unknown origin) degradation in human MCF7 cells assessed as maximum efficacy by immunoblotting analysis relative to control
Protac activity at ER/VHL (unknown origin) degradation in human MCF7 cells by immunoblotting analysis
Induction of estrogen receptor degradation in human MCF7 cells assessed as maximum efficacy relative to control
Assay data:2 Tested
Induction of estrogen receptor degradation in human MCF7
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Protac activity at XIAP (unknown origin)/ERalpha (unknown origin) assessed as protein degradation
Displacement of [3H]-17beta-estradiol to estrogen receptor (unknown origin)
Binding affinity to estrogen receptor beta LBD (unknown origin) expressed in yeast cells co-expressing YFP assessed as fold change in fluorescence at 10 uM incubated for 15 hrs in dark by fluorescence based UV-vis spectrophotometric analysis
Assay data:1 Active, 5 Tested
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