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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
DYRK1A SGC Tm panel (DSF)
MAPK1 SGC Tm panel (DSF)
MAPK1 Invitrogen Lab (UK) kinase screen (BI)
KDR Invitrogen Lab (UK) kinase screen (BI)
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested
Inhibition of ERK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of VEGFR2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human GST-tagged DYRK1A expressed in Escherichia coli using Woodtide as substrate in presence of [gamma-33P] ATP incubated for 30 mins by scintillation counter analysis
Inhibition of VEGFR-2 (unknown origin)
Assay data:9 Active, 8 Activity ≤ 1 µM, 10 Tested
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