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Inhibition of cdc25c-mediated cdc2 dephosphorylation in human HeLa cells at 50 to 100 nM after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibitory activity against cdc25C phosphatase
Assay data:1 Active, 3 Tested
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)
Assay data:4 Active, 10 Tested
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system at 100 uM after 2 hrs
Assay data:16 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system at 10 uM after 2 hrs
Assay data:1 Tested
Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs
Assay data:6 Tested
Inhibition of human Cdc25C
Assay data:4 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Inhibition of cdc25c phosphorylation in human HeLa cells at 50 to 100 nM after 24 hrs by Western blot analysis
Inhibitory activity against recombinant CDC25C
Assay data:6 Active, 6 Activity ≤ 1 µM, 12 Tested
Inhibition of recombinant human GST-tagged cdc25C phosphatase activity using 3-O-methyl fluorescein phosphate at 100 uM
Assay data:4 Active, 4 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
Assay data:2 Tested
Inhibition of recombinant phosphatase activity of Cdc25C catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay
Inhibition of CDC25C
Assay data:19 Tested
Induction of cdc25C phosphorylation in human HeLa cells assessed as cdc2 kinase dephosphorylation at Tyr15 in human HeLa cells at 250 to 500 nM after 24 to 48 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Induction of cdc25C phosphorylation in human HeLa cells at 250 to 500 nM after 24 to 48 hrs by Western blot analysis
Percent inhibition of cell division cycle 25 degree C at 50 uM
Assay data:49 Tested
RNAi Global Initiative pilot viability screen of human kinase and cell cycle genes
Assay data:5 Active, 840 Tested
Summary
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