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Inhibition of Saccharomyces cerevisiae S288c histone acetyltransferase assessed as acetylation of histone H3 at 0.6 to 0.8 mM by Western blotting
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Saccharomyces cerevisiae S288c histone acetyltransferase assessed as acetylation of histone H4 at 0.6 to 0.8 mM by Western blotting
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide and acetyl-coenzyme A as substrate assessed as release of coenzyme A at 56 1.3 nM incubated for 5 mins prior to acetyl-coenzyme A addition measured every 2 mins for 10 mins by ThioGlo1 assay relative to control
Inhibition of Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Gcn5 expressed in Escherichia coli BL21 using acetyl-coenzyme A as substrate assessed as release of coenzyme A incubated for 5 mins prior to acetyl-coenzyme A addition measured every 2 mins for 10 mins by ThioGlo1 assay
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using (H3-H4)2 peptide and acetyl-coenzyme A as substrate assessed as inhibition of H3K56 acetylation at 500 nM incubated for 5 mins prior to acetyl-coenzyme A addition measured after 30 mins by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Asf1-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using (H3-H4)2 peptide and acetyl-coenzyme A as substrate assessed as inhibition of H3K56 acetylation at 500 nM incubated for 5 mins prior to acetyl-coenzyme A addition measured after 30 mins by ELISA
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using acetyl-coenzyme A as substrate assessed as reduction of enzyme Vmax at 30 to 60 nM preincubated for 15 mins with H3n21 peptide followed by acetyl-coenzyme A addition measured for 10 mins by Michelis-Menton equation analysis
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide as substrate assessed as release of coenzyme A at 1.5 uM by ThioGlo1 assay relative to control
Irreversible inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide as substrate assessed as release of coenzyme A at 1.5 uM after 4 hrs by 10 fold dilution assay relative to control
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using acetyl-coenzyme A as substrate assessed as reduction of substrate Km at 30 to 60 nM preincubated for 15 mins with H3n21 peptide followed by acetyl-coenzyme A addition measured for 10 mins by Michelis-Menton equation analysis
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide as substrate assessed as reduction of enzyme Vmax at 30 to 200 nM preincubated for 15 mins with H3n21 peptide followed by acetyl-coenzyme A addition measured for 10 mins by Lineweaver-Burk plot analysis
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide as substrate assessed as reduction of substrate Km at 30 to 200 nM preincubated for 15 mins with H3n21 peptide followed by acetyl-coenzyme A addition measured for 10 mins by Lineweaver-Burk plot analysis
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide and acetyl-coenzyme A as substrate assessed as inhibition of histone acetylation at 1 uM
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide and acetyl-coenzyme A as substrate assessed as release of CoA at 0.3 to 10 uM preincubated for 5 mins with H3n21 followed by acetyl-coenzyme A addition measured after 30 mins by ThioGlo1 assay
Assay data:8 Tested
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide and acetyl-coenzyme A as substrate assessed as release of CoA at 0.1 to 1 uM preincubated for 5 mins with H3n21 followed by acetyl-coenzyme A addition measured after 30 mins by ThioGlo1 assay
Inhibition of histone acetyltransferase Rtt109 in Saccharomyces cerevisiae assessed as inhibition of H3K56 acetylation
Inhibition of histone acetyltransferase Rtt109 in Saccharomyces cerevisiae assessed as camptothecin-induced DNA damage
Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae 6xHis-tagged histone acetyltransferase Rtt109 using H3n21 peptide and acetyl-coenzyme A as substrate assessed as residual activity measured release of coenzyme A up to 100 uM incubated for 5 mins prior to acetyl-coenzyme A addition measured every 2 mins for 10 mins by ThioGlo1 assay relative to control
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