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Inhibition of gamma-secretase-mediated cleavage of amyloid precursor protein in human IMR32 cells after 2 hrs using MBPC-125 substrate by ELISA assay
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta42 level after 48 hrs by AlphaLISA assay
Assay data:17 Active, 15 Activity ≤ 1 µM, 20 Tested
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta40 level after 48 hrs by AlphaLISA assay
Assay data:15 Active, 5 Activity ≤ 1 µM, 20 Tested
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta42 level after 24 hrs by DELFIA assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta40 level after 24 hrs by DELFIA assay
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as increase of total amyloid beta level after 24 hrs by DELFIA assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta38 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 13 Tested
Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta38 production at 100 uM after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Assay data:24 Tested
Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta40 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Assay data:13 Tested
Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta40 production at 100 uM after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Assay data:1 Active, 37 Tested
Modulation of gamma-secretase in human SH-SY5Y cells over-expressing beta-APP C-terminal fragment SPA4CT assessed as amyloid beta40 level by electrochemiluminescent analysis
Assay data:17 Active, 1 Activity ≤ 1 µM, 25 Tested
Modulation of gamma-secretase in human SH-SY5Y cells over-expressing beta-APP C-terminal fragment SPA4CT assessed as amyloid beta42 level by electrochemiluminescent analysis
Assay data:23 Active, 13 Activity ≤ 1 µM, 25 Tested
Modulation of gamma-secretase mediated cleavage of NotchdeltaE in human HeLa cells assessed as release of Notch intracellular domain level by luminescence based luciferase assay
Assay data:2 Tested
Selectivity ratio of IC50 for gamma-secretase in human SH-SY5Y cells to IC50 for gamma-secretase mediated cleavage of NotchdeltaE in human HeLa cells
Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of total amyloid beta level after 24 hrs by DELFIA
Inhibition of gamma-secretase in human SNC-204B8 cells assessed as Amyloid beta protein 1-x level after 16 hrs by ELISA assay
Assay data:22 Active, 18 Activity ≤ 1 µM, 22 Tested
Inhibition of gamma-secretase-mediated notch cleavage in human SNC-204B8 cells after 16 hrs by luciferase reporter gene assay
Assay data:9 Active, 1 Activity ≤ 1 µM, 22 Tested
Selectivity ratio of IC50 for gamma-secretase-mediated Notch cleavage in human SNC-204B8 cells to IC50 for gamma-secretase-mediated amyloid precursor protein-cleavage in human IMR32 cells
Assay data:22 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
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