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Rat Nav1.7 (Voltage-gated sodium channels)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of slow inactivated rat NaV1.7 at -20 mV holding potential after 5 mins by IonWorks electrophysiology method
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rat NaV1.7 by cell based whole cell voltage clamp method
Assay data:11 Active, 6 Activity ≤ 1 µM, 13 Tested
Inhibition of NaV1.7 channel in rat DRG neurons assessed as reduction of TTX-sensitive sodium current by whole cell patch clamp assay
Assay data:1 Active, 1 Tested
Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp method
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of rat Nav1.7 expressed in HEK293T cells measured after 3 to 5 mins by patchXpress electrophysiology assay
Inhibition of rat Nav1.7 expressed in HEK293T cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay
Inhibition of Nav1.7 in C57BL/6 rat embryonic DRG cells assessed as blockade of spontaneous neuronal firing by Maestro microelectrode array analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of rat Nav1.7 assessed as reduction in peak inward current at -70 mV holding potential measured after 600 secs by manual patch clamp electrophysiology assay
Inhibition of rat NaV1.7
Inhibition of Nav1.7 in rat dorsal root ganglions at -60 mV holding potential by patch clamp assay
Inhibition of rat Nav1.7 expressed in HEK cells by patch clamp electrophysiology method
Inhibition of rat NaV1.7 at -125 mV holding potential yielding 20 to 50% inactivation after 3 to 5 mins by PatchXpress automated electrophysiology method
Assay data:4 Active, 5 Tested
Inhibition of NaV channel in rat DRG neurons under holding potential at -60 mV by patch clamp method
Assay data:12 Active, 17 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of 20% inactivated rat Nav1.7 expressed in HEK293T cells assessed as inhibition of sodium current measured for 3 to 5 mins by whole cell voltage clamp method
Inhibition of rat Nav1.7 channel by automated voltage clamp analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of rat NaV1.7 channel by two-electrode voltage-clamp method
Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of rat Nav1.7 by whole cell voltage-clamp electrophysiology assay
Inhibition of rat Nav1.7 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at 300 uM and at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
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