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Inhibition of mouse IRE1 assessed as reduction in XBP1 splicing using 5'-Alexa Fluor 647-CAUGUCCGCAGCGCAUG-BHQ1-3' as substrate preincubated for 30 mins followed by substrate addition by FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM preincubated for 4 hrs followed by three times compound washout and subsequent 1 mW/cm2 UV irradiation for 10 mins measured after 8 hrs by immunoblot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM measured after 4 hrs by immunoblot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM irradiated with 1 mW/cm2 UV light for up to 10 mins and measured after 4 hrs by immunoblot analysis
Assay data:1 Active, 1 Tested
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM measured after 2 days by immunoblot analysis
Assay data:2 Tested
Binding affinity to IRE1 in LPS-stimulated mouse primary B cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 2.5 to 5 uM measured after 2 hrs by immunoblot analysis
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 2.5 uM measured up to 4 hrs by immunoblot analysis
Assay data:3 Active, 3 Tested
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 5 uM measured after 24 hrs by immunoblot analysis
Assay data:2 Active, 2 Tested
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM measured after 3 days by immunoblot analysis
Assay data:6 Active, 6 Tested
Binding affinity to IRE1 in mouse 5TGM1 cells assessed as inhibition of IRE1/XBP1 pathway activation by measuring reduction in XBP1s expression at 10 uM measured up to 24 hrs by immunoblot analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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