BioAssay by Target (List) for Gene (Select 7177) - PubChem BioAssay - NCBI

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Select item 2135181.

Inhibitory activity of compound was determined against human Tryptase beta; NA= not active (<10% inhibition at 100 uM)

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:3 Tested

AID:: 213518

Summary PubMed Citation Related BioAssays by Target

Select item 2135052.

Compound was tested for inhibitory activity against tryptase; Not determined (value more than 0.0004)

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:2 Tested

AID:: 213505

Summary PubMed Citation Related BioAssays by Target

Select item 2135103.

Inhibitory potency against tryptase

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:15 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 17 Tested

AID:: 213510

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2135114.

Evaluated for its inhibitory potency against tryptase

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:50 Active, 11 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 57 Tested

AID:: 213511

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2135125.

Compound was evaluated for its binding affinity to the tryptase

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 213512

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2135136.

Inhibitor specificity constant ki/Ki was evaluated for the compound against tryptase; NI means No inhibition

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:1 Tested

AID:: 213513

Summary Related BioAssays by Target

Select item 2135157.

Inhibitory activity of compound was determined against human Tryptase beta

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 213515

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2135168.

In vitro inhibition of human Tryptase beta.

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:16 Active, 16 Activity ≤ 1 µM, 17 Tested

AID:: 213516

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2135179.

Inhibitory activity against human Tryptase beta was evaluated

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:5 Active, 4 Activity ≤ 1 µM, 7 Tested

AID:: 213517

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 21350410.

Inhibition of tryptase activity

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:16 Active, 6 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 20 Tested

AID:: 213504

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 23847911.

Inhibitory activity against human mast cell tryptase beta

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 238479

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 23853512.

In vitro inhibitory activity against tryptase

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:25 Active, 25 Activity ≤ 1 µM, 27 Tested

AID:: 238535

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 23900913.

Inhibitory activity against human Tryptase beta 2 expressed in yeast cells

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:15 Active, 12 Activity ≤ 1 µM, 15 Tested

AID:: 239009

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 24086714.

Inhibitory concentration against tryptase

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:9 Active, 14 Tested

AID:: 240867

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 24104715.

Inhibition concentration against beta tryptase was determined

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 241047

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 24109416.

Inhibitory concentration against alpha tryptase was determined

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:1 Active, 1 Tested

AID:: 241094

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 24368417.

Percentage inhibition against tryptase at 10 uM

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:38 Tested

AID:: 243684

Summary PubMed Citation Related BioAssays by Target

Select item 24383718.

Inhibitory activity against human Tryptase beta 2 expressed in yeast cells at 5 uM

Source:: ChEMBL

Protein Target:: Tryptase alpha/beta-1

Assay data:7 Tested

AID:: 243837

Summary PubMed Citation Related BioAssays by Target

Select item 21337619.

Binding affinity against human alpha tryptase

Source:: ChEMBL

Protein Targets:: Tryptase alpha/beta-1; ...
Total:: 3

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 213376

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190420.

siRNA Circadian Assay

Source:: The Genomics Institute of the Novartis Research Foundation (GNF)

Assay data:527 Active, 33364 Tested

AID:: 1904

Summary PubMed Citation Related BioAssays by Depositor

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (39)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (9)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (32)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (39)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (8)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (60)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (12)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (58)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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