BioAssay by Target (List) for Gene (Select 6833) - PubChem BioAssay - NCBI

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Select item 953261.

Percent maximal agonist response of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 2

Assay data:5 Tested

AID:: 95326

Summary PubMed Citation Related BioAssays by Target

Select item 939752.

Evaluated for K-ATP activity in terms of membrane potential change, through guinea pig bladder assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:51 Active, 1 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 51 Tested

AID:: 93975

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939763.

Evaluated for K-ATP activity as change in membrane potential in guinea pig bladder assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 93976

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939774.

Evaluated for K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:32 Active, 22 Activity ≤ 1 µM, 36 Tested

AID:: 93977

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939785.

K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:22 Active, 16 Activity ≤ 1 µM, 26 Tested

AID:: 93978

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939796.

Evaluated for K-ATP activity as stable twitch response through field-stimulated landrace pig detrusor assay (FSLPD)

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 93979

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939807.

Evaluated for K-ATP activity as stable twitch response through field-stimulated landrace pig detrusor assay (FSLPD)

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:1 Active, 1 Tested

AID:: 93980

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 939818.

Evaluated for K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 31 Tested

AID:: 93981

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 939829.

K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:7 Active, 4 Activity ≤ 1 µM, 25 Tested

AID:: 93982

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9398310.

Evaluated for K-ATP activity as stable twitch response through field-stimulated landrace pig detrusor assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 93983

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9398411.

Evaluated for K-ATP activity as in vitro bladder relaxation in spontaneous Landrace pig detrusor strips (SLPD)

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 93984

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9398512.

Evaluated for K-ATP activity as in vitro bladder relaxation in spontaneous Landrace pig detrusor strips (SLPD)

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 93985

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9532513.

Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 2

Assay data:5 Active, 3 Activity ≤ 1 µM, 8 Tested

AID:: 95325

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9397414.

Evaluated for K-ATP activity in terms of change in membrane potential through guinea pig bladder assay

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:64 Active, 37 Activity ≤ 1 µM, 68 Tested

AID:: 93974

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9532715.

Percent maximal agonist response of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes at 30 uM

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 2

Assay data:2 Tested

AID:: 95327

Summary PubMed Citation Related BioAssays by Target

Select item 9562316.

Percent inhibition of glibenclamide binding to K+ channel

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:7 Tested

AID:: 95623

Summary PubMed Citation Related BioAssays by Target

Select item 15942617.

In vitro maximal efficacy in stable twitch response in isolated Landrace pig bladder detrusor strips relative to P-1075

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:6 Tested

AID:: 159426

Summary PubMed Citation Related BioAssays by Target

Select item 15952918.

Maximal efficacy was expressed in comparison to P1075 using KATP activity in pig bladder strips

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:17 Tested

AID:: 159529

Summary PubMed Citation Related BioAssays by Target

Select item 15967219.

Potent effective concentration was evaluated for KATP channel opening activity in pig bladder strips

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested

AID:: 159672

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15967320.

In vitro functional potassium channel opening activity in tissue strips obtained from Landrace pig bladders(LPD)

Source:: ChEMBL

Protein Targets:: ATP-binding cassette sub-family C member 8; ...
Total:: 4

Assay data:9 Active, 11 Tested

AID:: 159673

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (42)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (34)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (48)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (85)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (83)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (14)
BioAssays deposited by other experimentalists

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