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Inhibition of binding of the radioligand, [125 I-Tyr0]-CRF to rat cerebral cortex membrane
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Effective concentration to inhibit CRF-mediated increase in adenylate cyclase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was tested for the inhibition of binding of the radioligand, [125 I-Tyr0]-CRF to rat cerebral cortex membrane
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Assay data:1 Active, 2 Tested
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.
Assay data:20 Active, 6 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 21 Tested
Compound was tested for the binding affinity to rat Corticotropin releasing factor (rCRF) receptors
Compound was tested for the binding affinity to rat ccorticotropin releasing factor receptor
Compound was tested for the binding affinity to rat corticotropin releasing factor receptor
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
In vitro binding affinity against CRF receptor in rat cortical homogenates
In vitro binding affinity against CRF receptor (alpha-helical) in rat cortical homogenates
SummaryPubMed CitationRelated BioAssays by Target
In vitro binding affinity to the CRF receptor in rat cortical homogenates
Assay data:29 Active, 11 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Rat CRF2 receptor (Corticotropin-releasing factor receptors)
Assay data:9 Active, 9 Tested
Compound was evaluated for affinity towards Corticotropin releasing factor receptor 2 expressing tissues such as Choroid plexus, blood vessels
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)
Assay data:1 Tested
In vitro ability (peptide) to stimulate ACTH release by rat anterior pituitary cells relative to Ovine corticotropin releasing factor (oCRF).
Assay data:27 Tested
Tested in vitro to antagonize CRF-induced release of ACTH by rat pituitary cells in culture
Assay data:20 Tested
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity at corticotropin releasing hormone receptor in rat frontal cortex homogenates by [125I]Tyr-o-CRF displacement.
Assay data:17 Active, 11 Activity ≤ 1 µM, 18 Tested
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