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A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
SummaryPubMed Citation
Activation of Bax mutant in human Jurkat cells assessed as increase in apoptosis rate at 10 uM after 72 hrs by DAPI staining
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Bax in human HuH7 cells assessed as formation of apoptotic nuclei at 10 uM by immunofluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Bax in human HuH7 cells assessed as induction of caspase-3 activation at 10 uM by immunofluorescence assay
Activation of Bax in human HuH7 cells assessed as cyt-C release from mitochondria by MitoTracker Red dye-based immunofluorescence assay
Induction of Bax translocation from cytoplasm to mitochondria in human HuH7 cells at 10 uM after 12 hrs by Western blot analysis
Activation of Bax in human HuH7 cells assessed as conformational changes by SDS-PAGE analysis
Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 72 hrs by spectrophotometric analysis
Assay data:2 Active, 2 Tested
Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 12 to 72 hrs by spectrophotometric analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 16 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Activation of Bax in human NB4 cells assessed as increase in apoptosis rate at 10 uM after 12 hrs by DAPI staining
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
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